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In myeloid cell lines there was a more differential effect: when quercetin and apigenin were used in combination with each topoisomerase II inhibitor, there was a synergistic/additive decrease in cell proliferation, cell accumulation in G 2 M and S phase of the cell cycle and an increase in apoptosis

Disease-associated glia in neurodegenerative diseases Chronic inflammatory responses and disease-associated glia are well known to contribute to the development of various neurodegenerative diseases

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Finally, many thankful regards go to Jorgete Constantin, Aparecida Pinto Munhos Hermoso and Renato Polimeni Constantin, from the University of Maring, Paran, Brazil, for their invaluable help during some experimental procedures