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Description

IGFBP-3 and IGFBP-5 production by human intestinal muscle: reciprocal regulation by endogenous TGF-beta1

Toxicol Sci 169:35364

A proline residue N-terminal to the FSFG motif (P H4 ) contacts the interface between H4 and H5

The standard conversion from rat to human doses uses a factor of approximately 6.2, meaning a rat dose of 10 g/kg translates to roughly 1.6 g/kg in humans