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One example of such GPCR is the protease-activated receptor 2 (PAR2), which is specifically expressed in the plasma membrane of endometrium epithelial cells and modulates intracellular calcium levels upon activation by serine proteases like trypsin

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Based on current evidence, AX represents a promising adjuvant nutraceutical in populations with metabolic inflexibility, including individuals with obesity, insulin resistance, and age-related muscle decline

However, oxidative stress can inhibit the expression of HIF-1 and magnify inflammation, which may impair the therapeutic effect of Mg 2+ in OA (Mobasheri et al., 2017)