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Mutation effects can be silent (with probability q sil ), lethal ( q let , resulting in the immediate removal of the cell), or affinity affecting ( q aa ) [10, 12, 14] (see Table I)

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Modified purine and pyrimidine bases represent a significant category of DNA damage induced by hydroxyl radicals, alongside other forms of damage, such as oligonucleotide strand breaks, DNAprotein cross-links, and abasic sites in DNA (Dizdaroglu et al., 2002[119])