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Deletion mutants were generated in MAP strain A1-157 through specialized transduction and found viable in vitro

Furthermore, pathway analysis of the DEGs identified several signaling pathways closely involved in hepatocyte differentiation of pluripotent stem cells

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This temporal pattern is consistent with the well-described phenomenon of GI adaptation to GLP-1 receptor activation, in which chronic receptor stimulation leads to desensitization of the vagal afferent pathways that mediate nausea and the enteric nervous system circuits that regulate gastric emptying and motility