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These include concerns regarding the long-term safety of gene modifications, challenges in the mass production of gene drugs, difficulties in controlling gene expression in vivo, limitations in achieving stable and long-term expression of foreign genes in vivo, low efficiency of targeted gene transfer, alterations in the biological properties of target cells, and ethical considerations

Diphenyleneiodonium chloride inhibits MYCN-amplified neuroblastoma by targeting MYCN induced mitochondrial alterations

[45], found GSH supplementation (50 M) declines leaf Cd content and increases SOD, APX, POD, and GR activity in Mexican cotton