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Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon

[0250] A kit for supporting the health, well-being and/or appearance of a users skin through the coordinated application to the oral cavity of a plurality of different toothpaste formulations is also contemplated and includes: [0251] a first container containing an amount of a first toothpaste formulation sufficient for a plurality of applications to a user, the first toothpaste formulation formulated to be administered to the user proximate to the user s waking and containing from about 0.1 to about 20 weight % of at least one active agent supporting skin elasticity and selected from the group consisting of aloe barbadensis, bilberry, coenzyme Q10, Vitamin E, glucosamine, honey, spirulina, hyaluronic acid, Vitamin C, SOLIDENTI, centella asiatica extract, polygonum cuspidatum root extract, Scutellaria baicalensis root extract, camellia sinensis leaf extract, glycyrrhiza glabra(licorice) root extract, chamomilla recutita(matricaria) flower extract, chamomilla recutita