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During ferroptosis, lipid radical formation is induced by the accumulation of ROS leading to plasma membrane lipid peroxides (Yang et al., 2014)

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At the same time, Keap1 becomes the substrate of the E3 ligase, attached to the holo-complex of Keap1-Nrf2 [24], and leads to the ubiquitination and proteasomal degradation of Keap1

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