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Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome

The consequent impact on spermatogenesis is profound, resulting in significantly reduced sperm count, motility, and increased sperm abnormalities and DNA fragmentation, which collectively impair fertilization potential and embryo development 11

Mediation of metabolism KEAP1 Loss of kelch-like ECH-associated protein 1 (KEAP1) leads to release of Nrf2, allowing its translocation to the nucleus, where it activates antioxidant gene transcription, helping cells counteract oxidative damage [81]

doi: 10.1016/j.freeradbiomed.2022.05.024 159 WangXShenTLianJDengKQuCLiEet al