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In the PNS, thiamine deficiency can result in polyneuritis and paralysis, as seen in dry beriberi, which affects the sensory system, causing pain, altered temperature sensitivity, numbness, reduced tendon reflexes, and leg atrophy ( Pan et al, in a in vivo study performed with transgenic mice, have shown that chronic treatment with benfotiamine, a thiamine derivate with better bioavailability, enhanced the spatial memory and reduced both amyloid plaque numbers and phosphorylated tau levels, suggesting that this thiamine derivative may be useful in clinical Alzheimers disease treatment, although others thiamine derivatives do not showed the same results ( Table 2 )

The starting dose of 2.5mg is sub-therapeutic for weight loss

Besides, the neurodegeneration found in hippocampal regions is also indicative of how prolonged exposure to high concentrations of fluoride may trigger cognitive damage

J Neurol 248:469477 Schousboe A (1981) Transport and metabolism of glutamate and GABA in neurons are glial cells