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5 GCN5L in cell stress responses The cellular stress response is a series of physiological and biochemical reactions that cells activate to maintain cellular homeostasis and viability when faced with stressful conditions such as oxidative stress, endoplasmic reticulum stress, metabolic stress, heat stress, and nutrient deprivation

These combined effects lead to the abnormal accumulation of unfolded or misfolded proteins, ultimately inducing ERS

Dietary tryptophan, tyrosine, and phenylalanine depletion induce reduced food intake and behavioral alterations in mice