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9 When a carnitine deficiency develops, long-chain fatty acids are not available for -oxidation and energy production, thereby causing excessive lipid accumulation in skeletal muscle, heart, and liver and ultimately, leading to cardiac myopathy and hepatomegaly

Increased 12/15-lipoxygenase leads to widespread brain injury following global cerebral ischemia

[22] Diphenhydramine acts as a reversible, competitive antagonist-and more precisely, an inverse agonist-at the histamine H receptor, thereby stabilizing the inactive receptor conformation and preventing histamine-mediated vasodilation, increased capillary permeability, and sensory nerve activation

Yan MM, Zhao H, Li ZR, Chow JW, Zhang Q, Qi YP, Wu SS, et al