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It should be noted though, that inappropriate administration of folate when there is a vitamin B12 deficiency may cause neurologic and hematologic relapse (Reynolds, 2014)

Poster presented at: American Academy of Neurology Annual Meeting 2024

Mice lacking CYP27B1 or VDR exhibit thymic atrophy, reduced AIRE + mTECs, impaired T cell negative selection, and gene expression profiles resembling those of aged thymic tissue [143]

Risks of Use in Patients with Increased Intracranial Pressure, Brain Tumors, Head Injury, or Impaired Consciousness In patients who may be susceptible to the intracranial effects of CO2 retention (e.g., those with evidence of increased intracranial pressure or brain tumors), acetaminophen and codeine phosphate tablets may reduce respiratory drive, and the resultant CO2 retention can further increase intracranial pressure