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We have chosen prpTDP-43 A315T mice for our analyses, because this mouse model of TDP-43 pathology was generated based on the A315T mutation detected in the TARDP gene of ALS patients, who had TDP-43 pathology in their cortex 19 , and because the mouse model strictly recapitulated many aspects of the disease, including progressive CSMN degeneration 16

Emerging research indicates that vitamin B12 deficiency in psychiatric populations is not merely a consequence of poor dietary habits but may also exacerbate neuropsychiatric symptoms - such as cognitive deficits, mood instability, and psychosis - potentially creating a vicious cycle

8 The variable orientation and organization of the elastic fibers within the IVD correlate heavily with regards to the differential loading patterns in the IVD

9 (4), R102R111