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M.HuizingaR.RonkenE.AdamsonP.et al (2001)

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A chromatin immunoprecipitation assay identified the NOX4 promoter region as a plausible site for Smad2/3/4 binding (Wang et al

The circulating half-life is short approximately 11 to 12 minutes which is why research protocols typically use small subcutaneous doses given at bedtime to align with the natural overnight GH pulse