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For decades, physicians focused on cholesterolparticularly LDL (bad cholesterol) and HDL (good cholesterol)as the main predictors of heart attack and stroke

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For instance, H4 lysine 12 lactylation (H4K12la) induces smooth muscle cell senescence by promoting the expression of aging-related genes, thereby accelerating atherosclerosis [20]

Animal studies confirm: offspring of caffeine-exposed rats showed abnormal methylation patterns on genes controlling adrenal hormone production, with 51.2% born growth-restricted.[28] Most alarming: these epigenetic effects carried forward into grandchildren never exposed to caffeine themselves.[17] Your Genes Determine Your Risk The CYP1A2 gene has a well-studied polymorphism (rs762551)