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In diurnal animals like the Nile grass rat, dim LAN paradoxically enhanced immune markers including plasma IgG and DTH, whereas in nocturnal rodents, such as Siberian hamsters and C57BL/6 mice, dim light exposure and phase shifts typically led to immune suppression, delayed wound healing, reduced febrile responses to lipopolysaccharide (LPS), and diminished bactericidal activity 93,94,95,96

152 In recent years, there has been a heightened focus on tau deposition, including the correlation between tau deposition, brain atrophy, and glucose metabolism in both typical and atypical AD, 167,168 as well as the effects of tau deposition at the molecular and cellular levels

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doi: 10.1038/nrd3003 51 TanakaYLuoYO'SheaJJNakayamadaS