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In this context, the gut microbiota not only serves as a target for drug action but also participates in the metabolic conversion of these drugs

doi: 10.1093/pcp/41.6.666 117 YangL.ZhangJ.HeJ.QinY.HuaD.DuanY.et al

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There is a paucity of literature to guide dosing but current subject matter expert consensus is to dose an additional 500mg IV/IO over 5 minutes and then an infusion of 10mg/kg/hr until clinical improvement is stable which may require infusion for more than 24 hours