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Before binding to specific DNA locus antioxidant response elements (AREs), Nrf2 will heterodimerize with Maf or Jun proteins in the nucleus (259, 260)

To confirm Andexxas clinical benefit AstraZeneca used data from the Phase IV ANNEXA-I study, which found that the drug could induce significantly better hemostasis in patients with acute intracranial bleeding than usual care

This ratio did not change in the semaglutide group [10]

Limitations across studies include reliance on rodent models and short-term outcomes, limited cell-specific genetics and safety data, frequent use of bulk LC3-II/p62 without rigorous flux assays, and focus on single pathways despite crosstalk between mTOR/AMPK, ubiquitination, and mitophagy