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34 The serum level of S100B, an astrocyte marker, increased when symptoms of the CNS appeared 36 and reflected destruction of the BBB, 38 which is conducive to invasion by SARS-CoV-2 and opens a vasculature path for the virus with inflammatory cytokines

For supplemental reading about optimizing endpoint quality in rare disease trials, visit this blog: 5 Tips for Success in Rare Disease Studies - Signant Health Adolescent schizophrenia Adolescent schizophrenia trials face significant challenges, particularly due to the lack of validated assessment tools tailored to this demographic

In the study, a longer-acting version of the NK2R ligand was created by covalently attaching a 16-carbon fatty acid conjugate of -glutamic acid, which is the same moiety used in the GLP1RA liraglutide, to the Lys2 residue of native NKA

The study showed a decrease in the size of adipocytes in subcutaneous adipose tissue after NMN treatment