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Despite the high sensitivity and negative predictive value of S100B in detecting traumatic intracranial hemorrhage, our review indicates that S100B has not been utilized as an efficacy indicator in animal acupuncture intervention models of TBI

However, due to the scale of the existing industrial commitment to producing the established kinds of preventive vaccines, application of preventive ICs may be limited to a few vaccine targets

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Acknowledgements The authors are grateful to Angelika Sawicka, and Joanna Jaworska, for their technical assistance