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89 Resistance due to Inactivation by Glutathione or GSTs Intracellular inactivation of alkylating agents has been implicated in human tumor resistance

Therefore, the relatively low abundance of lipoylation in untreated cells suggests that lipoylation is rate-limiting for the OGDHc, and our findings are consistent with the accumulation of Lp glu following ABHD11 inhibition, which reduces OGDHc activity (Fig

297 However, overexpression of PINK1 inhibit the mtDNA-cGAS-STING pathway, so impaired mitophagy boosts inflammatory responses by promoting mtDNA DAMPs in aging

In contrast to their protein-bound counterpart, FAAs can interact with specific receptors present on a wide variety of cells in various parts of the body, including the intestines, where they can activate specific intracellular pathways and confer physiological effects (34, 48)