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The reduction of Compound I back to its resting state can occur via the transfer of a hydrogen atom, involving either a His-mediated (FitaRossmann) mechanism where a distal histidine acts as an acidbase catalyst or a direct mechanism that allows for a hydrogen atom transfer

L-Glutathione: A naturally occurring compound that plays a role in various cellular functions

The -glutamyl amino acid can be transported back into the cell where -glutamyl cyclo-transferase (GCT) releases the acceptor amino acid to form 5-oxo-proline, the latter of which is converted back to glutamate by oxo-prolinase and used for GSH synthesis

oncogenes have been identified that encode membrane growth factor receptors, involved in the growth factor signaling pathway, whereas others encode cytoplasmic signaling molecules