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Perspective: targeting the JAK/STAT pathway to fight age-related dysfunction

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MRP-1 has been implicated in the etiology of a wide array of human pathologies, including inflammatory bowel disease, cystic fibrosis, Alzheimers disease, age-related macular degeneration, cardiovascular disease, and certain neurological disorders as well as tumor progression 10,11,12,13,14,15,16,17

Cassar JR, Mills EW, Demirci A (2022) Characterization of pulsed light for microbial inactivation

For example, exposure of porcine endothelial cells to trivalent arsenics caused an increase in total glutathione levels and higher enzymatic activity of GPX and GST, with no increase being observed in GSR-activity [51]