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Clinical variables We recorded years of education and body-mass index (BMI) for all participants

SD has been clinically or experimentally validated for diabetic foot ulcers, impaired wound healing, hyperglycaemia-induced endothelial dysfunction, platelet aggregation-related thrombosis, and even fracture repair and osteoporosis 10,11,12,13

Polymer formation or loosening is induced in situ , involving oxidative processes mediated by different ROS types, such as superoxide (O 2 - ), hydrogen peroxide (H 2 O 2 ) and hydroxyl radical formation (Liszkay et al ., 2004