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Blood-based biomarkers for Alzheimers disease: towards clinical implementation

Charnas, R., EU Perspective on Regulatory Issues for Biologics. Feb 29, 2008

These pathways include the metabolisms of urea cycle, glycine and serine, arginine and proline, methionine, aspartate, betaine, ammonia recycling, alanine, spermidine and spermine biosynthesis, tryptophan, purine, glutamate and methylhistidine (Figures 5A,B)