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From a bioindication perspective, it has been also emphasized that the determination of concentrations in both the liver and kidney, rather than in the liver alone, may increase the likelihood of identifying cases of poisoning or high exposure to certain elements, for example, lead (Wayland et al

Table 2.26B

(81) found that NLRP3(-/-) mice generated fewer proinflammatory cytokines in colonic tissue and experienced less severe colitis than wild-type mice after oral DSS administration