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However, monotherapeutic approaches risk incomplete pathway suppression and multidrug resistance induction, necessitating development of combinatorial regimens targeting multiple EMP nodes to achieve durable therapeutic efficacy

Nevertheless, these studies collectively highlight the vast potential of SQOR as a therapeutic targetranging from engineered microbes for environmental bioremediation to metabolic modulation and small-molecule drugs for disease interventionunderscoring the immense promise of SQOR-targeted strategies