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SLC39A8 gene encoding a metal ion transporter: discovery and bench to bedside

El Beshlawy, A., Mohtar, G., Abd El, Ghafar E., Abd El Dayem, S

As these pumps translocate structurally-unrelated drugs, their overexpression triggered by exposure of cancer cells to one drug leads to the resistance to several others, thereby conferring a multidrug resistance (MDR) phenotype