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Researchers have also discovered a compound, ferroptosis-inducer-56 (FIN56), that can degrade GPX4 and deplete coenzyme Q10 (CoQ10) via the mevalonate pathway, thus initiating ferroptosis ( via chaperone-mediated autophagy is another approach to induce ferroptosis ( Figure 1 )

Then, the researchers explored whether their targeted approach could be used to deliver treatment directly to the site of cancer cells, which would eliminate the biggest drawback of chemotherapy and other cancer treatments: toxicity to the whole body

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Synthesis, characterization and in vitro anticancer activity of C-5 Curcumin analogues with potential to inhibit TNFinduced NFB activation