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This difference occurred by the 4th week (28 weeks) of drug administration (Figure 2C)

Alternatively, perhaps sites of ER-mitochondrial contact facilitate spatially restricted exchange of glutathione as they do for other metabolites such as calcium and reactive oxygen species (Joseph, Booth, Young, & Hajnoczky, 2019)

However, since GHcy-SO 2 H contains a CS bond rather than an SS bond, it cannot undergo the final hydrolytic step of the catalytic cycle and instead accumulates as a dead-end product, leading to time-dependent inactivation of the enzyme ( -glutamyl transpeptidase ( FIGURE 12 TST TST, also known as rhodanese, is a mitochondrial matrix enzyme that participates in both cyanide detoxification and mitochondrial sulfide oxidation (Way, 1984)

Supplementary Materials The following supporting information can be downloaded at: Author Contributions Conceptualization, R.F