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As an example, Clinical studies of silymarin SMEDDS demonstrated a 3.64.1-fold increase in AUC and a 4-fold increase in C max compared to conventional extracts, with t 1 / 2 extending from 2.5 to 6.1 h ( max of 812.43 ng/mL at 0.8 h and of 676.98 ngh/mL