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Keap1 possesses a BTB domain, a C-terminal Kelch domain, and an intervening region (IVR), and functions as the substrate recognition module of a Cullin3-based E3 ligase complex (Keap1/Cullin3/Rbx1) (Dinkova-Kostova et al

All translation elongation factors and the e, f, and h subunits of translation initiation factor 3 are encoded by 5-terminal oligopyrimidine (TOP) mRNAs

Consequently, ROS damage the different parts of cells, including lipids, proteins and nucleic acid that leads to several chronic and degenerative conditions like aging, dementia, cardiovascular diseases, kidney diseases, neurodegeneration, cancer, respiratory disorder, rheumatoid arthritis as well as several other metabolic ailments [2]

Slide-seq: a scalable technology for measuring genome-wide expression at high spatial resolution