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According to the GBD 2021 study published in The Lancet Neurology , 11.9 million individuals experienced their first stroke in 2021, resulting in 7.25 million deaths and 160 million disability-adjusted life years (DALYs) (127)

In contrast, our study confirmed decreased glutathione levels and increased ROS levels through BSO treatment or GCLC silencing, and revealed that while the depletion of glutathione did not compromise lymphoma cell survival in 2D culture, it sharply diminished viability in 3D gels