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melanotan 1

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Description

SIRT3, a class III HDAC associated with longevity, deacetylates Forkhead box protein O3a (FOXO3a) and promotes transcription of antioxidant enzymes (e.g., manganese superoxide dismutase and catalase), thereby constraining mitochondrial ROS and preserving redox homeostasis [71, 72]

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Histopathologic analysis of the colonic biopsies confirmed the presence of severe melanosis

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