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Prospective studies indicated that repeated use of therapeutic APAP dosage may slightly increase the level of serum ALT without manifest acute liver failure (Zimmerman and Maddrey, 1995)

A high ratio of reduced to oxidized antioxidants increases the reducing potential of the cellular antioxidant system (Jena et al

During puberty, for example, IGF-I bioactivity is increased (114)

Collectively, these observations establish that NRF2 alone can sustain sufficient transcriptional output to maintain cancer cell line growth and that metabolic reprogramming of cells driven by NRF2 does not require redox buffering via enhanced glutathione production