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Esto no es terico: es la razn por la que la terapia con HGH exgena tiene restricciones precisas en oncologa

(96) found that EGCG blocked the transition of VSMCs from G1 to S phase by initiating the expression of p21/WAF1, which in turn inhibited NF-kappaB and AP-1-mediated VSMC proliferation

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The oxidative metabolism of glutamate through GLUD activity generates substantial adenosine triphosphate (ATP), with ammonia and carbon dioxide as byproducts (93), significantly contributing to ammonia buildup in the TME ( Figure 3 )