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Among surviving patients, the most severely affected patients have intellectual disability, progressive cerebellar disease and ataxia, recurrent bacterial infections, and chronic metabolic acidosis and hemolytic anemia

FDAs introductory briefing document states that the agency does not intend to issue a final determination until it has considered input from the advisory committee process and finalized its reviews

82,84 Genetic testing for ApoE variants may help an individual better understand the genetic contribution of their ApoE status to their risk for atherosclerosis

Spines with strong synaptic contacts typically have a large spine head, which connects to the dendrite via a membranous neck