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Bottom line : Licorice is a great skincare ingredient with significant depigmenting, anti-inflammatory and even some antioxidant properties

In vitro, it upregulates extracellular matrix genes (COL1A1, elastin, decorin) while suppressing inflammatory cytokines

The researchers concluded that short-term DSIP treatment is unlikely to be a major therapy for chronic insomnia, though it may have minor benefits

Reported Mild Effects: Temporary injection site redness Slight drowsiness (when dosed in evening) Vivid dreams or altered sleep patterns Mild headaches during initial days Management Strategies: Rotate injection sites regularly Reduce dosage if effects seem excessive Maintain hydration throughout protocol Consider timing adjustments for sleep-related effects When to Modify or Discontinue Certain situations warrant protocol modifications or discontinuation