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Saponins Saponins are one of the secondary metabolite groups in medicinal herbs, exhibiting immunomodulatory properties using a variety of mechanism

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Maiti A, DiNardo C, Rausch C, Pemmaraju N, Garcia-Manero G, Ohanian M, Daver N, Issa G, Borthakur G , Ravandi F, Alvarado Y, Kadia T, Jabbour E, Short N, Montalban-Bravo G, Jain N, Kornblau S, Masarova L, Wierda W, Sasaki K, Takahashi K, Yilmaz M, Burger J, Estrov Z, Verstovsek S, Andreeff M, Bose P, Ferrajoli A, Thompson P, Montalbano K, Vaughan K, Bivins C, Pierce S, Qiao W, Ning J, Welch J, Kantarjian H, Konopleva M

A Nuanced Interpretation of the Data The absence of evidence is not evidence of absence, but in this case, the volume of available data across multiple populations, decades, and dosing regimens is substantial