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Structural and biophysical analyses demonstrated high-affinity copper binding to PDK1, enhancing its interaction with AKT and activating downstream -catenin signaling

Studies indicate that PS exposure induces mitochondrial cristae fragmentation, reduces membrane potential, and inhibits electron transport chain complex activity in murine brainscollectively exacerbating ROS generation

Nearly all of KMT2A rearrangements are classified as translocation mutations, which produce a fusion protein that binds to the menin protein, triggering the development of leukemia

Forty-eight male albino rats aged 810 months, with mean weights of 410 18.6 g were randomized into four groups ( n = 12 in each group): no IP (group 1)