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Description

The underlying mechanisms include that MANF physically binds to Ser35 of CK19 to inhibit CK19 membrane translocation, MANF facilitates the formation of a complex with CK19 and NICD2, and cytosolic CK19 interacts with AR domain of NICD2 to suppress NICD2 degradation and activate its nuclear signaling, thus accelerating the transformation of mature hepatocytes to ICC cells

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PMID: 3622582

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Iron metabolism and lipid peroxidation signaling are increasingly recognized as central mediators of ferroptosis

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It also has to manage appetite, metabolic flexibility, and inflammation in a way that allows progress to continue long enough to become visible

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