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There are several causes of LUTS such as benign prostate enlargement, detrusor muscle weakness or overactivity, prostate inflammation (prostatitis), urinary tract infection, prostate cancer, and neurological disease (1)

Retatrutide has been tested at up to 12 mg weekly in Phase 2 and Phase 3 trials

Pro-inflammatory cytokines such as TNF- can bind to corresponding receptors and activate signaling pathways like NF-B and MAPK, which in turn induce the expression of pro-inflammatory factors like IL-1 and IL-6, thereby exacerbating the inflammatory response (Hirano, 2021

GABAergic synapses: their plasticity and role in sensory cortex