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10.1681/ASN.2012060628 J

This strategy offers a high degree of specificity and minimizes the impact on the microbiome [88]

Consistent with expectations, bona fide p53 targets including HDM2 and CDKN1A were among the most highly up-regulated genes in Control cells, whereas genes known to be negatively regulated by p53, such as E2F2 , were strongly down-regulated (el-Deiry et al, 1993