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's study separated rats into five groups, and the immunohistochemistry results indicate that DSS (0.5, 1.0, and 2.0 mg/kg) significantly increased Bcl-2 expression in the cerebral area, while simultaneously inhibiting the expression of Bax and caspase-3

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However, more studies are still warranted for further exploration of other mechanistic molecular targets that may play role in the pathophysiology of cyclophosphamide-induced neurotoxicity such as involvement of protein oxidation and mitochondrial DNA damage in mediating this adverse effect

Ellipse was merged into Syneron Candela in the United States in 2018