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More recent research has explored AOD9604 for other potential applications beyond obesity, including osteoarthritis treatment based on observations of cartilage regeneration properties in preclinical models, though clinical validation of these additional indications is limited

These compounds effectively reduced MNAM levels in adipose tissue, liver, and plasma, leading to improved insulin sensitivity and decreased body weight

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These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance