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R 1 is selected from the group consisting of: amino, substituted amino, alkoxy, substituted alkoxy, C1-C12 alkyl, C1-C12 substituted alkyl, C1-C12 alkenyl, C1-C12 substituted alkenyl, C1-C12 alkynyl, C1-C12 substituted alkynyl, Ci-C 6 alkyl aryl, Ci-C 6 substituted alkyl aryl, Ci-C 6 alkenyl aryl, Ci-C 6 substituted alkenyl aryl, Ci-C 6 alkynyl aryl, Ci-C 6 substituted alkynyl aryl, norleucine, tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, threonine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, norleucine, ornithine, S- benzyl cysteine, O-benzyl serine, O-benzyl threonine, cyclohexylalanine, 4-tetrahydropyranyl- glycine, and azaleucine

This dual approach can enhance efficacy while reducing irritation: you get an ongoing low-level dose from retinyl palmitate even as the stronger retinol is working upfront

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[ 200 ] RANKL mediates BACH1's nuclear transportation and attenuates NRF2mediated antioxidant enzymes, thus increasing intracellular ROS signaling and osteoclastogenesis in mice