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Key Benefits: Beyond the Gut Benefit: Tissue Repair Focus Area: Tendons, Ligaments, Bone Mechanism of Action: Accelerates fibroblast growth and collagen synthesis

B3 (Niacin) is widely recognised for its ability to improve skin tone, reduce redness, and support the skins barrier function

198,199 Moreover, NRXNs are critical for Ca 2+ -triggered neurotransmitter release but are not required for synapse formation, which has also been demonstrated in knockout mice

Conclusion: Although clinical trials in PBC provide an important measure of effectiveness based on liver biochemistries, studies in RW settings have demonstrated the benefit of OCA on long-term outcomes, as the medication has been used in regular clinical practice since its accelerated approval in 2016