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For instance, since one of the products of the reaction catalysed by gulonolactone oxidase is hydrogen peroxide, Halliwell suggested in 2001 that the loss of biosynthesis balanced the "cost" of production, since the advantage of producing one vitamin C molecule would be lost by the production of this reactive oxygen species (Halliwell 2001)

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A major advancement in astrocyte research came with the identification of their reactive properties, facilitated by the discovery of glial fibrillary acidic protein (GFAP) as a reliable marker of astrocyte activation 4