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Through its interaction with NOTCH1, CHAC1/BOTCH inhibits NOTCH1 activity and thereby prevents neuronal stem cell self-renewal (Scheckhuber et al., 2007)

At the innate immunity level, PRLMs attenuate persistent inflammation by suppressing neutrophil and PMN chemotaxis, migration, and proinflammatory cytokine release

Exposure to environmental toxins: exposure to pollutants and toxins can increase oxidative stress, which leads to a decrease in the level of glutathione in the body, which in turn negatively affects the skin

For instance, studies conducted on rats demonstrated positive effects of AOX therapy on endometriosis-related infertility (146)